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Categories: Healthy Aging

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The first comprehensive cell atlas of aging human muscle reveals the intricate genetic and cellular processes behind muscle deterioration and mechanisms to counteract it.

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Researchers have discovered the connection between aldehydes, organic compounds produced by cells as part of metabolic processes, and rapid aging. Their findings indicate a potential treatment for diseases that lead to accelerated aging as well as a means to counteract aging in healthy people by controlling exposure to aldehyde-inducing substances including alcohol, pollution, and smoke.

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Scientists have identified sugar abnormalities in the blood that may promote biological aging and inflammation in people living with HIV.

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Scientists discovered that the biological instructions within these vesicles differed significantly in postmortem brain samples donated from patients suffering from Alzheimer's disease.

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Pregnancy may carry a cost, reports a new study. The research shows that women who reported having been pregnant looked biologically older than women who had never been pregnant, and women who had been pregnant more often looked biologically older than those who reported fewer pregnancies.

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Children and teens from racial and ethnic minority groups are disproportionately affected by persistent insomnia symptoms that begin in childhood and continue through young adulthood, according to a new study. This study is one of the first to look at how childhood insomnia symptoms evolve over the long-term and investigate how the trajectory of insomnia differs between racial and ethnic groups.

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Certain RNA molecules in the nerve cells in the brain last a life time without being renewed. Neuroscientists have now demonstrated that this. RNAs are generally short-lived molecules that are constantly reconstructed to adjust to environmental conditions. The research group hopes to decipher the complex aging process of the brain and gain a better understanding of related degenerative diseases.

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In old age, a tighter interlinkage between different domains of functional capacity may indicate a loss of system resilience. When functional capacity domains are tightly interconnected, a disruption in one domain can affect others and lead to a collapse in functioning. It is therefore important to look at functioning as a whole and to take care of the different aspects of physical and mental well-being.

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Most human nerve cells last a lifetime without renewal. A trait echoed within the cells' components, some enduring as long as the organism itself.

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Cell damage from oxidative stress is a major underlying cause of age-related cognitive and muscle strength decline. Antioxidants can reduce oxidative stress and prevent age-related health decline. A new study has found that mice administered with a blended antioxidant supplement show significant improvements in spatial cognition, short-term memory, and mitigated age-related muscle decline. The study suggests that blended antioxidant supplements hold promise as a dietary intervention for health issues associated with aging.

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A smartphone app could enable greater participation in clinical trials for people with frontotemporal dementia (FTD), a devastating neurological disorder that often manifests in midlife.

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A new bioluminescence imaging technique has created highly detailed, and visually striking, images of the movement of oxygen in the brains of mice. The method, which can be easily replicated by other labs, will enable researchers to more precisely study forms of hypoxia in the brain, such as the denial of oxygen to the brain that occurs during a stroke or heart attack. The new research tool is already providing insight into why a sedentary lifestyle may increase risk for diseases like Alzheimer's.

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Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show. When the team transplanted bone marrow stem cells from mice carrying a hereditary version of Alzheimer's disease into normal lab mice, the recipients developed Alzheimer's disease -- and at an accelerated rate.

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Researchers report that mature oligodendrocytes -- the central nervous system cells critical for brain function -- cling to life following a fatal trauma for much, much longer than scientists knew. The findings suggest a new pathway for efforts to reverse or prevent the damage that aging and diseases such as multiple sclerosis cause to these important cells.

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Just as you can't make an omelet without breaking eggs, scientists have found that you can't make long-term memories without DNA damage and brain inflammation.

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Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.

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Researchers say they have discovered that the protein puromycin-sensitive aminopeptidase (NPEPPS) plays a role in regulating response to platinum chemotherapy in patients with bladder cancer.

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Those with aging immune systems struggle to fight off novel viruses and respond weakly to vaccination. Researchers were able to revitalize the immune system in mice.

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Dedicated memory tests on smartphones enable the detection of 'mild cognitive impairment', a condition that may indicate Alzheimer's disease, with high accuracy.

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Tardigrade proteins are potential candidates in technologies centered on slowing the aging process and in long-term storage of human cells.