Showing 20 articles starting at article 1
Categories: Schizophrenia
Published Understaffed nursing homes in disadvantaged neighborhoods more likely to overuse antipsychotics
(via sciencedaily.com) Original source Nursing homes in disadvantaged communities are more likely to overmedicate residents with antipsychotics, especially homes that are understaffed, according to a new study.
Published Two key brain systems are central to psychosis
(via sciencedaily.com) Original source When the brain has trouble filtering incoming information and predicting what's likely to happen, psychosis can result, research shows.
Published Pilot study shows ketogenic diet improves severe mental illness
(via sciencedaily.com) Original source A small clinical trial found that the metabolic effects of a ketogenic diet may help stabilize the brain.
Published Reverse effects of trauma? Older brain cells linger unexpectedly before their death
(via sciencedaily.com) Original source Researchers report that mature oligodendrocytes -- the central nervous system cells critical for brain function -- cling to life following a fatal trauma for much, much longer than scientists knew. The findings suggest a new pathway for efforts to reverse or prevent the damage that aging and diseases such as multiple sclerosis cause to these important cells.
Published Schizophrenia and aging may share a common biological basis
(via sciencedaily.com) Original source Researchers have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with schizophrenia and from older adults. These changes suggest a common biological basis for the cognitive impairment often seen in people with schizophrenia and in the elderly.
Published Bullied teens' brains show chemical change associated with psychosis
(via sciencedaily.com) Original source Researchers have found that adolescents being bullied by their peers are at greater risk of the early stages of psychotic episodes and in turn experience lower levels of a key neurotransmitter in a part of the brain involved in regulating emotions. The finding suggests that this neurotransmitter may be a potential target for pharmaceutical interventions aimed at reducing the risk of psychotic disorders.
Published Firing nerve fibers in the brain are supplied with energy on demand
(via sciencedaily.com) Original source To rapidly transmit electrical signals in the brain, the long nerve fibers are insulated by specialized cells called oligodendrocytes. These cells also respond to the electrical signals of active nerve fibers and provide them with energy on demand, as researchers have discovered. If this process, regulated by potassium, is disabled in mice, the nerve fibers are severely damaged as the animals age -- resembling the defects of neurodegenerative diseases.
Published Vigilant monitoring is needed to manage cardiac risks in patients using antipsychotics, doctors say
(via sciencedaily.com) Original source The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation, reports a new study. Caution is advised to manage cardiac risks in patients prescribed these medications, the authors of the study and an accompanying editorial say.
Published Study reveals function of little-understood synapse in the brain
(via sciencedaily.com) Original source New research for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer's disease, to a type of brain cancer known as glioma. Neuroscientists focused on the synapse connecting neurons to a non-neuronal cell, known as oligodendrocyte precursor cells. OPCs can differentiate into oligodendrocytes, which produce a sheath around nerves known as myelin. Myelin is the protective sheath covering each nerve cell's axon -- the threadlike portion of a cell that transmits electrical signals between cells.
Published Clinical predictive models created by AI are accurate but study-specific, researchers find
(via sciencedaily.com) Original source Scientists were able to show that statistical models created by artificial intelligence (AI) predict very accurately whether a medication responds in people with schizophrenia. However, the models are highly context-dependent and cannot be generalized.
Published Quest for personalized medicine hits a snag
(via sciencedaily.com) Original source The quest for personalized medicine, a medical approach in which practitioners use a patient's unique genetic profile to tailor individual treatment, has emerged as a critical goal in the health care sector. But a new study shows that the mathematical models currently available to predict treatments have limited effectiveness.
Published Unravelling the association between neonatal proteins and adult health
(via sciencedaily.com) Original source Scientists studied two complement components that are important parts of the immune system and are linked to schizophrenia and autoimmune disorders. They studied the link between two protein concentrations -- C3 and C4 -- in over 68,000 newborn babies and the risk of developing six mental disorders later in life.
Published An unexpected link between 2 schizophrenia risk proteins
(via sciencedaily.com) Original source The discovery of a physical interaction between two proteins in brain cells that can be traced in mice to control of movement, anxiety and memory could one day open the door to development of new schizophrenia treatment strategies, researchers say.
Published New clues to early development of schizophrenia
(via sciencedaily.com) Original source Schizophrenia is a severe neuropsychiatric disease that remains poorly understood and treated. Schizophrenia onset is typically in adolescence or early adulthood, but its underlying causes are thought to involve neurodevelopmental abnormalities. Because human prenatal and postnatal brain tissue is exceedingly difficult to procure and therefore study, researchers have had limited opportunities to identify early disease mechanisms, especially during the critical prenatal period. Now, a pair of studies use new technology to study schizophrenia in models of early human brain development.
Published Brain connectivity is disrupted in schizophrenia
(via sciencedaily.com) Original source Schizophrenia, a neurodevelopmental disorder that features psychosis among its symptoms, is thought to arise from disorganization in brain connectivity and functional integration. Now, a new study finds differences in functional brain connectivity in people with and without psychosis and schizophrenia that could help researchers understand the neural underpinnings of this disease.
Published AI language models could help diagnose schizophrenia
(via sciencedaily.com) Original source Scientists have developed new tools, based on AI language models, that can characterize subtle signatures in the speech of patients diagnosed with schizophrenia.
Published Scientists take next big step in understanding genetics of schizophrenia
(via sciencedaily.com) Original source Scientists are figuring out which of the 5,000 variants associated with schizophrenia have an actual causal effect in the development of the condition that affects millions of people worldwide.
Published Schizophrenia genetic risk factor impairs mitochondrial function
(via sciencedaily.com) Original source Researcher discovers possible link of mitochondrial function to the development of schizophrenia.
Published New neuroimaging approach could improve diagnosis of schizophrenia
(via sciencedaily.com) Original source New research has identified age-related changes in brain patterns associated with the risk for developing schizophrenia. The discovery could help clinicians identify the risk for developing mental illness earlier and improve treatment options.
Published Schizophrenia is associated with somatic mutations occurring in utero
(via sciencedaily.com) Original source As a psychiatric disorder with onset in adulthood, schizophrenia is thought to be triggered by some combination of environmental factors and genetics, although the exact cause is still not fully understood. Researchers have now found a correlation between schizophrenia and somatic copy-number variants, a type of mutation that occurs early in development but after genetic material is inherited. This study is one of the first to rigorously describe the relationship between somatic -- not inherited -- genetic mutations and schizophrenia risk.