Showing 20 articles starting at article 1
Categories: Healthy Aging
Published The vicious cycle of protein clumping in Alzheimer's disease and normal aging
(via sciencedaily.com) Original source To date, approaches to treatments for Alzheimer's disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins. Researchers have recently completed a systematic study in worms that paints an intricate picture of the connections between insoluble proteins in neurodegenerative diseases and aging. Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health.
Published Research sheds light on how proteins linked to Alzheimer's disease influence neuronal growth
(via sciencedaily.com) Original source New research has shed light in the complex interplay between cell proteins, and how they impact on neurons in neurodevelopmental disorders and Alzheimer's disease.
Published Alzheimer's disease without symptoms: How is that possible?
(via sciencedaily.com) Original source Everyone experiences aging in their own way, and factors such as genetics, lifestyle and environment play a role in this process. Some individuals reach the age of 90 or even 100 in good health, without medications or brain disease. But how do these individuals maintain their health as they age?
Published Study links sleep apnea severity during REM stage to verbal memory decline
(via sciencedaily.com) Original source A research team has revealed the link between the frequency of sleep apnea events during the rapid-eye-movement stage and the severity of verbal memory impairment in older adults at risk for Alzheimer's disease. Verbal memory refers to the cognitive ability to retain and recall information presented through spoken words or written text and is particularly vulnerable to Alzheimer's.
Published Genes driving age-related blood cell mutations uncovered
(via sciencedaily.com) Original source New research identifies a larger pool of genes involved in clonal haematopoiesis than previously thought, and their implications for disease and diagnostic tests.
Published Some brain cells age faster and are more prevalent in Alzheimer's
(via sciencedaily.com) Original source Engineers have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer's disease. Additionally, researchers observed male-female-specific differences in the aging process of certain brain cells, with the female cortex exhibiting a higher ratio of 'old' oligodendrocytes to 'old' neurons compared to the male cortex. The discoveries were made possible by a new technique called MUSIC (multinucleic acid interaction mapping in single cells), which allows researchers to peek inside individual brain cells and map out interactions between chromatin--which is the tightly coiled form of DNA -- and RNA.
Published Distinct population of 'troublemaker' platelet cells appear with aging, lead to blood clotting, disease
(via sciencedaily.com) Original source Researchers have discovered a distinct, secondary population of platelets that appears with aging and have hyperreactive behavior and unique molecular properties, which could make them easier to target with medication.
Published Discrimination may accelerate aging
(via sciencedaily.com) Original source Discrimination may speed up the biological processes of aging, according to a new study.
Published How biological aging clocks tick
(via sciencedaily.com) Original source Aging clocks can measure the biological age of humans with high precision. Biological age can be influenced by environmental factors such as smoking or diet, thus deviating from the chronological age that is calculated using the date of birth. The precision of these aging clocks suggests that the aging process follows a program. Scientists have now discovered that aging clocks actually measure the increase in stochastic changes in cells.
Published Who should receive preventive treatment for TB? Individuals of all ages with positive skin or blood test
(via sciencedaily.com) Original source Researcher found that exposed individuals with confirmed TB infection -- i.e. a positive skin or blood test -- should receive priority treatment in settings with a low prevalence of the disease, regardless of their age. However, in high-burden settings, all exposed individuals should be considered for preventative treatment, even without a confirmed infection. This strategy can help end the tuberculosis epidemic and support global public health efforts to reduce TB mortality by 95 percent by 2035 (from 2015 estimates).
Published Damaging impact of heat waves on vital organs
(via sciencedaily.com) Original source Researchers have found evidence of the molecular causes of the damaging impact heat stress causes on the gut, liver and brain in the elderly. These findings point to the potential of developing precise prognostic and therapeutic interventions.
Published Could getting enough sleep help prevent osteoporosis?
(via sciencedaily.com) Original source In people's early- to mid-20s, they reach what is called peak bone mineral density, which is higher for men than it is for women, according to researchers. This peak is one of the main determinants of fracture risk later in life. After reaching this peak, a person's bone density remains roughly stable for a couple of decades. Then, when women enter the menopausal transition, they experience accelerated bone loss. Men also experience bone density decline as they age. Sleep patterns also evolve over time.
Published How E. coli get the power to cause urinary tract infections
(via sciencedaily.com) Original source New research examines how the bacteria Escherichia coli, or E. coli -- responsible for most UTIs -- is able to use host nutrients to reproduce at an extraordinarily rapid pace during infection despite the near sterile environment of fresh urine.
Published Small molecule shows early-stage promise for repairing myelin sheath damage
(via sciencedaily.com) Original source A breakthrough study appears to overcome difficulties that have long frustrated previous attempts to reverse a form of nerve damage that robs people with MS of motor control and gradually blunts cognitive functions for many people as they age.
Published Uncovering the secret of long-lived stem cells
(via sciencedaily.com) Original source Researchers have discovered that the enzyme cyclophilin A, which is produced in large amounts in hematopoietic stem cells, is key for these cells to retain their regenerative potential and avert the effects of aging via an unexpected mechanism.
Published The aspirin conundrum: Navigating negative results, age, aging dynamics and equity
(via sciencedaily.com) Original source A new study examining the role of aspirin in breast cancer treatment reveals critical issues related to health equity and aging that have broad implications for cancer and other disease intervention trials, say researchers.
Published People with rare longevity mutation may also be protected from cardiovascular disease
(via sciencedaily.com) Original source Patients with growth hormone receptor deficiency, or Laron syndrome, appear to have lower than average risk factors for cardiovascular disease, according to a new study.
Published RNA modification is responsible for the disruption of mitochondrial protein synthesis in Alzheimer's disease
(via sciencedaily.com) Original source A team of researchers has identified a mechanism that causes mitochondrial dysfunction in Alzheimer's patients resulting in a reduction of the supply of energy to the brain.
Published Good heart health in middle age may preserve brain function among Black women as they age
(via sciencedaily.com) Original source Cognitive decline among Black women linked to poor heart health in middle age.
Published Wake up and die: Human brain neurons re-entering the cell cycle age quickly shift to senescence
(via sciencedaily.com) Original source Post-mitotic neurons in the brain that re-enter the cell cycle quickly succumb to senescence, and this re-entry is more common in Alzheimer's disease, according to a new study. The phenomenon may provide an opportunity to learn more about the neurodegeneration process, and the technique used to make this discovery is readily applicable to other inquiries about unique populations of cells in the brain.