Showing 20 articles starting at article 1
Categories: Crohn's Disease
Published Apply single-cell analysis to reveal mechanisms of a common complication of Crohn's disease
(via sciencedaily.com) Original source Study identifies key pathways underlying perianal fistula, a disease complication that is more prevalent and severe in African American populations.
Published Scientists discover the cellular functions of a family of proteins integral to inflammatory diseases
(via sciencedaily.com) Original source In a scientific breakthrough, researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.
Published New Inflammatory Bowel Disease testing protocol could speed up diagnosis
(via sciencedaily.com) Original source Patients with suspected inflammatory bowel disease (IBD) could benefit from better testing protocols that would reduce the need and lengthy wait for potentially unnecessary colonoscopies, a new study has found.
Published Hope for treating autoimmune diseases
(via sciencedaily.com) Original source A routine blood test that measures a patient's inflammation levels could improve the early diagnosis and management of a wide range of debilitating autoimmune diseases. The Systemic Inflammation Index (SII) uses information from routine laboratory data to measure inflammation in the body and examining this index in a new way could provide vital answers.
Published Gene analysis generates spatial map of intestinal cells and traces their trajectories during gut inflammation
(via sciencedaily.com) Original source Cells within the intestines perform various roles including nutrient absorption, sensing, and maintaining homeostasis. Certain chronic disorders are distinctly characterized by gut inflammation, which disrupts intestinal cells and can lead to a remodeling of the gut and the introduction of new immune cells. To better understand the types of cells and their positioning within the intestines, researchers used a new technique known as MERFISH (multiplexed-error robust-fluorescence in situ hybridization) to analyze 940 genes in 1.35 million intestinal cells in a mouse model of colitis.
Published Implantable sensor could lead to timelier Crohn's treatment
(via sciencedaily.com) Original source Scientists have developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn's disease. The approach offers long-term, real-time monitoring and could enable clinicians to act earlier to prevent or limit the permanent damage caused by inflammatory episodes.
Published New understanding of the gut immune system may hold promise for Crohn's disease patients
(via sciencedaily.com) Original source Scientists uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn's disease. The discovery may help define how to treat patients with severe Crohn's disease.
Published Treating newly-diagnosed Crohn's patients with advanced therapy leads to dramatic improvements in outcomes
(via sciencedaily.com) Original source A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.
Published Mood interventions may reduce inflammation in Crohn's and Colitis
(via sciencedaily.com) Original source New research reveals that interventions which improve mood can reduce levels of inflammation in people with inflammatory bowel disease by 18 per cent, compared to having no mood intervention.
Published Researchers reveal prevalence of persistent symptoms in patients with microscopic colitis
(via sciencedaily.com) Original source A new study examines how multiple factors contribute to the miscommunication and understanding of the digestive disease, microscopic colitis.
Published Comprehensive guideline on using biomarkers for monitoring Crohn's disease
(via sciencedaily.com) Original source New AGA guideline outlines reliable blood and stool tests to monitor inflammation that can reduce how often patients need invasive endoscopy.
Published Early life exposure to broccoli sprouts protects against colitis in inflammatory bowel disease
(via sciencedaily.com) Original source High fiber diets, like those that include broccoli sprouts or other cruciferous vegetables, may reduce disease symptoms and improve quality of life in patients with inflammatory bowel disease (IBD).
Published Body changes up to eight years before inflammatory bowel disease diagnosis
(via sciencedaily.com) Original source Researchers have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn's disease and up to three years before a diagnosis of ulcerative colitis.
Published Risk of serious infection even in low-active IBD
(via sciencedaily.com) Original source Inflammatory bowel disease (IBD) is an independent risk factor for serious infection, even at very low levels of gastrointestinal inflammation.
Published A promising target to fight inflammatory bowel diseases
(via sciencedaily.com) Original source Inflammatory bowel diseases (IBDs), such as Crohn's disease or ulcerative colitis, arise when there is a dysregulation of cell signalling pathways, leading to a chronic inflammatory response. The gut inflammatory response relies on a chain reaction involving several molecules, including RIPK2 -- known to be a good target for inhibitors treating IBDs. Researchers from the Cusack group at EMBL Grenoble have provided new insights into the interactions between RIPK2 and XIAP, another molecule involved in the inflammatory response, during the downstream chain reaction. These results, when taken together with previous structural biology studies on RIPK2, offer valuable information for the development of therapeutics to treat inflammatory bowel diseases.
Published Fungi used in food production could lead to new probiotics
(via sciencedaily.com) Original source According to a new study, 2 fungi used to produce food products have potential probiotic effects on gut inflammation.
Published Inflammatory bowel disease linked to atopic dermatitis
(via sciencedaily.com) Original source Adults with atopic dermatitis (AD) have a 34 percent increased risk of developing new-onset inflammatory bowel disease (IBD) compared with individuals who do not have the skin condition, and children have a 44 percent increased risk, according to a new study.
Published Developing a less invasive test for inflammatory bowel disease
(via sciencedaily.com) Original source Millions of Americans have inflammatory bowel disease (IBD), which occurs in one of two forms: Crohn's disease or ulcerative colitis. Though the two have similar symptoms, they require different treatment strategies, and tests to distinguish between them are invasive. Researchers now show that chains of sugar molecules are tacked onto antibodies differently in patients with the diseases, which could someday lead to a simple blood-based diagnostic test.
Published Neonatal stem cells from the heart could treat Crohn's disease
(via sciencedaily.com) Original source Research found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn's disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage. The study offers a promising new and alternative treatment approach that avoids the pitfalls of current Crohn's disease medications, including diminishing effectiveness, severe side effects and increased risk of gastrointestinal dysfunction.
Published Nanomedicine for treating inflammatory bowel disease
(via sciencedaily.com) Original source Chronic inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, is on the rise worldwide. The benefits of current medications are limited by problematic side effects. A research team has now introduced a new method of treatment. It is based on nanoparticles that mimic a special carbohydrate layer (glycocalyx) located on inflamed bowel cells, and which trigger anti-inflammatory effects in the diseased sites in the intestine.