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Published Advance in the treatment of acute heart failure identified
(via sciencedaily.com) Original source A multicenter study has identified a potential new treatment for acute heart failure, a leading cause of hospitalization and death.
Published RNA modification is responsible for the disruption of mitochondrial protein synthesis in Alzheimer's disease
(via sciencedaily.com) Original source A team of researchers has identified a mechanism that causes mitochondrial dysfunction in Alzheimer's patients resulting in a reduction of the supply of energy to the brain.
Published Vitamin D alters mouse gut bacteria to give better cancer immunity
(via sciencedaily.com) Original source Researchers have found that vitamin D encourages the growth of a type of gut bacteria in mice which improves immunity to cancer.
Published Food in sight? The liver is ready!
(via sciencedaily.com) Original source What happens in the body when we are hungry and see and smell food? A team of researchers has now been able to show in mice that adaptations in the liver mitochondria take place after only a few minutes. Stimulated by the activation of a group of nerve cells in the brain, the mitochondria of the liver cells change and prepare the liver for the adaptation of the sugar metabolism. The findings could open up new avenues for the treatment of type 2 diabetes.
Published Nanomaterial that mimics proteins could be basis for new neurodegenerative disease treatments
(via sciencedaily.com) Original source A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.
Published Identifying a new liver defender: The role of resident macrophages
(via sciencedaily.com) Original source Researchers discovered liver resident macrophages' pivotal role in defending against gut bacteria and related substances entering via the portal vein, particularly under compromised intestinal barrier conditions. Identified as 'sentinel macrophages,' they are activated by isoallo-lithocholic acid. This finding holds promise for developing preventive and therapeutic strategies for liver chronic inflammatory diseases, such as metabolic dysfunction-associated steatohepatitis (MASH), by enhancing the function of these macrophages to mitigate inflammation and improve treatment efficacy.
Published Genetic variations may predispose people to Parkinson's disease following long-term pesticide exposure, study finds
(via sciencedaily.com) Original source A new study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson's disease.
Published AI in medicine: The causality frontier
(via sciencedaily.com) Original source Machines can learn not only to make predictions, but also to handle causal relationships. An international research team shows how this could make therapies safer, more efficient, and more individualized.
Published National trial safely scaled back prescribing of a powerful antipsychotic for the elderly
(via sciencedaily.com) Original source Warning letters can safely cut prescribing of a powerful but risky antipsychotic, according to a new study. Researchers used Medicare data to study the effects of the letters on hundreds of thousands of older adults with dementia. They found a significant and lasting reduction in prescribing but no signs of adverse effects on patient health.
Published Solving the riddle of the sphingolipids in coronary artery disease
(via sciencedaily.com) Original source Investigators have uncovered a way to unleash in blood vessels the protective effects of a type of fat-related molecule known as a sphingolipid, suggesting a promising new strategy for the treatment of coronary artery disease.
Published Use of acid reflux drugs linked to higher risk of migraine
(via sciencedaily.com) Original source People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a new study. The acid-reducing drugs include proton pump inhibitors such as omeprazole and esomeprazole, histamine H2-receptor antagonists, or H2 blockers, such as cimetidine and famotidine, and antacid supplements.
Published Artificial intelligence can develop treatments to prevent 'superbugs'
(via sciencedaily.com) Original source Cleveland Clinic researchers developed an artficial intelligence (AI) model that can determine the best combination and timeline to use when prescribing drugs to treat a bacterial infection, based solely on how quickly the bacteria grow given certain perturbations. PNAS recently published their findings.
Published After spinal cord injury, neurons wreak havoc on metabolism
(via sciencedaily.com) Original source Conditions such as diabetes, heart attack and vascular diseases commonly diagnosed in people with spinal cord injuries can be traced to abnormal post-injury neuronal activity that causes abdominal fat tissue compounds to leak and pool in the liver and other organs, a new animal study has found.
Published A flexible microdisplay can monitor brain activity in real-time during brain surgery
(via sciencedaily.com) Original source A thin film that combines an electrode grid and LEDs can both track and produce a visual representation of the brain's activity in real-time during surgery -- a huge improvement over the current state of the art. The device is designed to provide neurosurgeons visual information about a patient's brain to monitor brain states during surgical interventions to remove brain lesions including tumors and epileptic tissue.
Published Good heart health in middle age may preserve brain function among Black women as they age
(via sciencedaily.com) Original source Cognitive decline among Black women linked to poor heart health in middle age.
Published Neurons spoil your appetite
(via sciencedaily.com) Original source A brain circuit inhibits food intake during nausea.
Published New research shows 'profound' link between dietary choices and brain health
(via sciencedaily.com) Original source New research has highlighted the profound link between dietary choices and brain health.
Published It takes two to TANGO: New strategy to tackle fibrosis and scarring
(via sciencedaily.com) Original source A study has now successfully controlled the effects of collagen hypersecretion at the cellular level. The experimental treatment consists of designer peptides which interrupt the interaction between TANGO1 and cTAGE5, two proteins important for collagen secretion. Experiments with patient-derived human cells and zebrafish showed the peptides are effective, non-toxic, and their effects reversible. The results pave the way for the development of new treatments that improve the cosmetic effects of scarring, relieve the symptoms of autoimmune diseases such as scleroderma, or help prevent the development of fibrosis, a more serious condition attributed to 45% of deaths in the industrialized world.
Published CAR T cell therapy targeting HER2 antigen shows promise against advanced sarcoma in phase I trial
(via sciencedaily.com) Original source Researchers have published results of a phase I clinical trial of a novel immunotherapy for high-risk sarcomas.
Published Social media can be used to increase fruit and vegetable intake in young people
(via sciencedaily.com) Original source Researchers have found that people following healthy eating accounts on social media for as little as two weeks ate more fruit and vegetables and less junk food.