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Published Different brain structures in females lead to more severe cognitive deficits after concussion than males
(via sciencedaily.com) Original source Important brain structures that are key for signaling in the brain are narrower and less dense in females, and more likely to be damaged by brain injuries, such as concussion. Long-term cognitive deficits occur when the signals between brain structures weaken due to the injury. The structural differences in male and female brains might explain why females are more prone to concussions and experience longer recovery from the injury than their male counterparts.
Published The vicious cycle of protein clumping in Alzheimer's disease and normal aging
(via sciencedaily.com) Original source To date, approaches to treatments for Alzheimer's disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins. Researchers have recently completed a systematic study in worms that paints an intricate picture of the connections between insoluble proteins in neurodegenerative diseases and aging. Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health.
Published Researchers wrestle with accuracy of AI technology used to create new drug candidates
(via sciencedaily.com) Original source Researchers have determined that a protein prediction technology can yield accurate results in the hunt to efficiently find the best possible drug candidates for many conditions.
Published New gene delivery vehicle shows promise for human brain gene therapy
(via sciencedaily.com) Original source In an important step toward more effective gene therapies for brain diseases, researchers have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein. Because the vehicle binds to a well-studied protein in the blood-brain barrier, the scientists say it has a good chance at working in patients.
Published Singing repairs the language network of the brain after a cerebrovascular accident
(via sciencedaily.com) Original source Singing rehabilitates speech production in post-stroke aphasia. Researchers investigated the rehabilitative effect of singing on the brain.
Published Celiac disease: New findings on the effects of gluten
(via sciencedaily.com) Original source Celiac disease is a chronic autoimmune condition that occurs in around one per cent of the world's population. It is triggered by the consumption of gluten proteins from wheat, barley, rye and some oats. A gluten-free diet protects celiac patients from severe intestinal damage.
Published Very early blood pressure control confers both benefits and harms in acute stroke
(via sciencedaily.com) Original source Early identification of stroke type could be key to harnessing the benefits of very early in-ambulance blood pressure lowering treatment in patients with suspected acute stroke, according to new research.
Published Why do we overindulge?
(via sciencedaily.com) Original source If you tend to do other things or get distracted while eating dinner, you may be running the risk of over-consuming everyday pleasures later, possibly because the distraction caused you to enjoy yourself less, according to new research.
Published 'Trojan horse' weight loss drug more effective than available therapies
(via sciencedaily.com) Original source A groundbreaking article describes a promising new therapy for obesity that leads to greater weight loss in mice than existing medications. The approach smuggles molecules into the brain's appetite center and affects the brain's neuroplasticity.
Published Blood pressure drugs more than double bone-fracture risk in nursing home patients
(via sciencedaily.com) Original source New research finds a link between common medications and life-threatening injuries.
Published Pre- and post-surgical immunotherapy improves outcomes for patients with operable lung cancer
(via sciencedaily.com) Original source Compared with pre-surgical (neoadjuvant) chemotherapy alone, adding perioperative immunotherapy -- given before and after surgery -- significantly improved event-free survival (EFS) in patients with resectable early-stage non-small cell lung cancer(NSCLC), according to researchers.
Published Infertility treatment doubles the risk of postpartum heart disease
(via sciencedaily.com) Original source Researchers tie infertility treatment to a particular risk for hypertensive diseases.
Published Research sheds light on how proteins linked to Alzheimer's disease influence neuronal growth
(via sciencedaily.com) Original source New research has shed light in the complex interplay between cell proteins, and how they impact on neurons in neurodevelopmental disorders and Alzheimer's disease.
Published Exploring the mechanism behind drug eruptions in the skin
(via sciencedaily.com) Original source Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used genetically engineered mice to demonstrate the role of HLA in mediating intracellular reactions in keratinocytes, leading to drug eruptions in the skin. Their findings could lead to improved preventive and treatment measures for drug eruptions.
Published Longer sprint intervals can improve muscle oxygen utilization compared to shorter intervals
(via sciencedaily.com) Original source Sprint interval training (SIT) is a form of exercise characterized by cycles of intense exercise which are interspersed by short durations of rest. In a recent study, researchers deep dive into the intricate connections among various parameters of SIT, such as duration and repetitions, and the resulting physiological responses. Their findings can aid in developing well-informed and tailored sprint training regimens that significantly benefit the modern-day population.
Published Fighting fat and inflammation: Scientists develop powerful new compounds
(via sciencedaily.com) Original source Obesity and inflammatory diseases are increasing in prevalence and contribute to the growing burden of lifestyle disorders such as diabetes and hypertension. There is a lack of naturally derived alternatives to tackle these issues. Researchers have synthesized novel amino acid derivatives of menthol and studied its properties. The menthyl esters showed exceptional anti-inflammatory and anti-obesity activities during preclinical studies and can be developed as therapeutic compounds with further research.
Published New cardiac research will save women's lives by improving detection of heart failure
(via sciencedaily.com) Original source An important new study has advanced how heart failure is detected in women -- meaning more female patients can be diagnosed and at an earlier stage.
Published Robots' and prosthetic hands' sense of touch could be as fast as humans
(via sciencedaily.com) Original source Research could pave the way for a prosthetic hand and robot to be able to feel touch like a human hand. The technology could also be used to help restore lost functionality to patients after a stroke.
Published Drug compounds to combat neurodegenerative diseases
(via sciencedaily.com) Original source Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins. Prion disease is an umbrella term for a group of fatal and currently untreatable neurodegenerative diseases that not only affect humans, but also wild and captive animals. These diseases include Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (BSE, or 'mad cow disease'), and chronic wasting disease (CWD) affecting deer, elk and moose.
Published Alzheimer's disease without symptoms: How is that possible?
(via sciencedaily.com) Original source Everyone experiences aging in their own way, and factors such as genetics, lifestyle and environment play a role in this process. Some individuals reach the age of 90 or even 100 in good health, without medications or brain disease. But how do these individuals maintain their health as they age?